An artificial metalloenzyme with the kinetics of native enzymes

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Cross‐Regulation of an Artificial Metalloenzyme

Cross-regulation of complex biochemical reaction networks is an essential feature of living systems. In a biomimetic spirit, we report on our efforts to program the temporal activation of an artificial metalloenzyme via cross-regulation by a natural enzyme. In the presence of urea, urease slowly releases ammonia that reversibly inhibits an artificial transfer hydrogenase. Addition of an acid, w...

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ژورنال

عنوان ژورنال: Science

سال: 2016

ISSN: 0036-8075,1095-9203

DOI: 10.1126/science.aah4427